Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behçet's disease. | Available online http content 10 1 R16 Research article Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behẹet s disease Yohei Kirino1 Mitsuhiro Takeno1 Reikou Watanabe1 Shuji Murakami1 Masayoshi Kobayashi1 Haruko Ideguchi1 Atsushi Ihata1 Shigeru Ohno1 Atsuhisa Ueda1 Nobuhisa Mizuki2 and Yoshiaki Ishigatsubo1 Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine 236-0004 3-9 Fukuura Kanazawa-ku Yokohama Japan department of Ophthalmology and Visual Science Yokohama City University Graduate School of Medicine 236-0004 3-9 Fukuura Kanazawa-ku Yokohama Japan Corresponding author Yoshiaki Ishigatsubo ishigats@ Received 25 Jul 2007 Revisions requested 30 Aug 2007 Revisions received 6 Nov 2007 Accepted 31 Jan 2008 Published 31 Jan 2008 Arthritis Research Therapy 2008 10 R16 doi ar2367 This article is online at http content 10 1 R16 2008 Kirino et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Toll-like receptors TLRs mediate signaling that triggers activation of the innate immune system whereas heme oxygenase HO -1 an inducible heme-degrading enzyme that is induced by various stresses suppresses inflammatory responses. We investigated the interaction between TLR and HO-1 in an inflammatory disorder namely Behget s disease. Methods Thirty-three patients with Behget s disease and 30 healthy control individuals were included in the study. Expression levels of HO-1 TLR2 and TLR4 mRNA were semiquantitatively analyzed using a real-time PCR technique and HO-1 protein level was determined by .
