Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study. | Available online http content 10 2 R32 Research article Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis a cohort study Koert M Dolman1 2 Nannette Brouwer2 Florine NJ Frakking1 Berit Flat03 Paul PTak4 Taco W Kuijpers1 2 0ystein F0rre3 and Anna Smerdel-Ramoya3 Department of Pediatric Hematology Immunology and Infectious diseases Emma Children s Hospital Academic Medical Center University of Amsterdam Meibergdreef Amsterdam 1105 AZ The Netherlands department of Blood Cell Research Sanquin Research at CLB and Landsteiner Laboratory University of Amsterdam Plesmanlaan Amsterdam 1066 CX The Netherlands department of Rheumatology Rikshospitalet University Hospital Sognsvannsveien Oslo NO-0027 Norway division of Clinical Immunology and Rheumatology Academic Medical Center University of Amsterdam Meibergdreef Amsterdam 11 05 AZ The Netherlands Corresponding author Florine NJ Frakking Received 18 Dec 2007 Revisions requested 6 Feb 2008 Revisions received 29 Feb 2008 Accepted 11 Mar 2008 Published 11 Mar 2008 Arthritis Research Therapy 2008 10 R32 doi ar2386 This article is online at http content 10 2 R32 2008 Dolman et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Background Mannose-binding lectin MBL is an innate immune protein. The aim of our study was to determine whether genetically determined MBL deficiency is associated with susceptibility to juvenile rheumatoid arthritis JRA and whether MBL2 genotypes are associated with JRA severity. Methods In a retrospective cohort study of 218 patients with polyarthritis n 67 and oligoarthritis n 151 clinical and laboratory
