Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Exogenous tumour necrosis factor α induces suppression of autoimmune arthritis. | Available online http content 10 1 R38 Research article Exogenous tumour necrosis factor a induces suppression of autoimmune arthritis Eugene Y Kim1 Howard H Chi1 Rajesh Rajaiah1 and Kamal D Moudgil1 2 Department of Microbiology and Immunology University of Maryland School of Medicine Baltimore MD USA. division of Rheumatology Department of Medicine University of Maryland School of Medicine Baltimore MD USA. Corresponding author Kamal D Moudgil kmoud001@ Received 7 Jan 2008 Revisions requested 14 Feb 2008 Revisions received 12 Mar 2008 Accepted 1 Apr 2008 Published 1 Apr 2008 Arthritis Research Therapy 2008 10 R38 doi ar2393 This article is online at http content 10 1 R38 2008 Kim et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Our previous studies showed that arthritic Lewis LEW rats produced the highest levels of tumour necrosis factor TNF a in the recovery phase of adjuvant arthritis AA suggesting a correlation between high TNFa levels and reduced severity of arthritis. To further explore this correlation we compared the TNFa secretion profile of the AA-resistant Wistar Kyoto WKY rats with that of LEW rats determined the effect of exogenous TNFa on the course of AA in LEW rats and examined various mechanisms involved in TNFa-induced disease modulation. Methods A cohort each of LEW and WKY rats was immunised subcutaneously with heat-killed Mycobacterium tuberculosis H37Ra Mtb . At different time points thereafter subgroups of rats were killed and their draining lymph node cells were tested for cytokine production. Another group of LEW rats was injected with TNFa intraperitoneally daily for a total of 10 injections 3
