Báo cáo y học: "Gout in the spotlight"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Gout in the spotlight. | Available online http content 10 3 112 Editorial Gout in the spotlight Alexander So Service of Rheumatology Centre Hospitalier Universitaire Vaudois 1011 Lausanne Switzerland Corresponding author Alexander So Published 6 June 2008 Arthritis Research Therapy 2008 10 112 doi ar2396 This article is online at http content 10 3 112 2008 BioMed Central Ltd See related research article by Pessler et al. http content 10 3 R64 Abstract Understanding how uric acid crystals provoke inflammation is crucial to improving our management of acute gout. It is well known that urate crystals stimulate monocytes and macrophages to elaborate inflammatory cytokines but the tissue response of the synovium is less well understood. Microarray analysis of mRNA expression by these lining cells may help to delineate the genes that are modulated. Employing a murine air-pouch model a number of genes expressed by innate immune cells were found to be rapidly upregulated by monosodium urate crystals. These findings provide new research avenues to investigate the physiopathology of gouty inflammation and may eventually lead to new therapeutic targets in acute gout. In this issue of Arthritis Research Therapy Pessler and colleagues 1 report on mRNA microarray analyses on the equivalent of the synovial lining cells after monosodium urate MSU crystals were injected into a murine air-pouch their study addresses the early phase 9 hours of the tissue response to gouty inflammation. Research on gout and how MSU crystals induce inflammation has recently taken a step forward emerging from the comparative shadows of rheumatoid arthritis research into the spotlight. In particular two key publications have challenged our previous ideas about the role of MSU in inflammation. Rock and colleagues 2 showed that urate crystals behaved like an adjuvant stimulating the immune system s response to dying cells and .

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