Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis. | Available online http content 10 2 R45 Research article A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis Allison L Smitten1 Teresa A Simon2 Marc C Hochberg3 and Samy Suissa4 1Duke University School of Medicine Duke South Durham NC 27710 USA 2Global Pharmacovigilance and Epidemiology Bristol-Myers Squibb Company 311 Pennington-Rocky Hill Road Hopewell NJ 08534 USA 3Division of Rheumatology and Clinical Immunology University of Maryland School of Medicine 10 S. Pine St. MSTF 8-34 Baltimore MD 21201 USA 4Division of Clinical Epidemiology McGill University Health Centre Royal Victoria Hospital 687 Pine Ave West Montreal QC H3A 1A1 Canada Corresponding author Samy Suissa Received 30 Aug 2007 Revisions requested 8 Oct 2007 Revisions received 5 Mar 2008 Accepted 23 Apr 2008 Published 23 Apr 2008 Arthritis Research Therapy 2008 10 R45 doi ar2404 This article is online at http content 10 2 R45 2007 Smitten et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The risk of malignancies in patients with rheumatoid arthritis RA has raised some concern particularly with immunosuppressive approaches to disease management. Methods We conducted a systematic review of the literature and meta-analysis characterizing the associated risk of overall malignancy and four site-specific malignancies lymphoma lung colorectal and breast cancer in patients with RA. A Medline search from 1990 to 2007 was conducted using specified search terms and predefined inclusion criteria for identification of relevant observational studies that provide estimates of relative risk of malignancy .
