Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha. | Available online http content 10 2 R47 Research article Prolonged granulocyte-macrophage colony-stimulating factor-dependent neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha Greg Parsonage Andrew Filer Magdalena Bik Debbie Hardie Sian Lax Katherine Howlett Leigh D Church Karim Raza See-Heng Wong Emily Trebilcock Dagmar Scheel-Toellner Mike Salmon Janet M Lord and Christopher D Buckley Rheumatology Research Group MRC Centre for Immune Regulation Institute for Biomedical Research University of Birmingham Vincent Drive Edgbaston Birmingham B15 2TT UK Corresponding author Christopher D Buckley Received 16 Nov 2007 Revisions requested 20 Dec 2007 Revisions received 31 Mar 2008 Accepted 23 Apr 2008 Published 23 Apr 2008 Arthritis Research Therapy 2008 10 R47 doi ar2406 This article is online at http content 10 2 R47 2008 Parsonage et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction A surprising feature of the inflammatory infiltrate in rheumatoid arthritis is the accumulation of neutrophils within synovial fluid and at the pannus cartilage boundary. Recent findings suggest that a distinct subset of IL-17-secreting T-helper cells TH17 cells plays a key role in connecting the adaptive and innate arms of the immune response and in regulating neutrophil homeostasis. We therefore tested the hypothesis that synovial fibroblasts bridge the biological responses that connect TH17 cells to neutrophils by producing neutrophil survival factors following their activation with IL-17. Methods IL-1 7-expressing cells in the rheumatoid synovium and IL-17-expressing cells in the peripheral .
