Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity. | Available online http content 10 3 R63 Open Access Research article Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity Morten A Karsdal1 Suzi H Madsen1 Claus Christiansen1 Kim Henriksen1 Amanda J Fosang2 and Bodil C Sondergaard1 1Nordic Bioscience A S Herlev Hovedgade 207 DK-2730 Herlev Denmark 2University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute Royal Children s Hospital Flemington Road Parkville 3052 Melbourne Victoria Australia Corresponding author Morten A Karsdal mk@ Received 27 Nov 2007 Revisions requested 27 Feb 2008 Revisions received 11 May 2008 Accepted 30 May 2008 Published 30 May 2008 Arthritis Research Therapy 2008 10 R63 doi ar2434 This article is online at http content 10 3 R63 2008 Karsdal et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Physiological and pathophysiological cartilage turnover may coexist in articular cartilage. The distinct enzymatic processes leading to irreversible cartilage damage compared with those needed for continuous self-repair and regeneration remain to be identified. We investigated the capacity of repair of chondrocytes by analyzing their ability to initiate an anabolic response subsequent to three different levels of catabolic stimulation. Methods Cartilage degradation was induced by oncostatin M and tumour necrosis factor in articular cartilage explants for 7 11 or 17 days. The catabolic period was followed by 2 weeks of anabolic stimulation insulin growth factor-I . Cartilage formation was assessed by collagen type II formation PIINP . Cartilage degradation was measured by .
