Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Lack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis. | Available online http content 10 4 R80 Research article Lack of association or interactions between the IL-4 IL-4Ra and IL-13 genes and rheumatoid arthritis Ioanna Marinou Simon H Till David J Moore and Anthony G Wilson Section of Musculoskeletal Sciences School of Medicine Biomedical Sciences The University of Sheffield Royal Hallamshire Hospital Beech Hill road Sheffield S10 2RX UK Corresponding author Anthony G Wilson Received 23 Apr 2008 Revisions requested 10 Jun 2008 Revisions received 18 Jun 2008 Accepted 14 Jul 2008 Published 1 4 Jul 2008 Arthritis Research Therapy 2008 10 R80 doi ar2454 This article is online at http content 10 4 R80 2008 Marinou et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction A feature of rheumatoid arthritis RA is an imbalance between proinflammatory and anti-inflammatory cytokines. Several recent studies have implicated polymorphism in the IL-4 signalling pathway in the development of erosive RA. The aim of the present study was to investigate the role of polymorphism in the IL-4 IL-4Ra and IL-13 genes in RA including an examination of epistasis. Methods A total of 965 Caucasian patients with RA cases and 988 healthy control individuals controls were genotyped for five variants in the IL-4 IL-13 gene cluster and two functional variants IL-4Ra . Individual genotype and haplotype frequencies were compared between cases and controls. The odd ratios were calculated with asymptotic 95 confidence intervals and P values less than were considered statistically significant. The potential association with radiological joint damage was also examined. Potential gene .
