Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration. | Available online http content 10 4 R86 Research article Intervertebral disc cells as competent phagocytes in vitro implications for cell death in disc degeneration Philip Jones1 2 Lucy Gardner1 2 Janis Menage1 Gwyn T Williams2 and Sally Roberts1 2 Open Access Centre for Spinal Studies Robert Jones Agnes Hunt Orthopaedic District Hospital NHS Trust Oswestry Shropshire SY10 7AG UK institute of Science and Technology in Medicine Keele University Keele Staffordshire ST5 5BG UK Corresponding author Sally Roberts Received 8 Apr 2008 Revisions requested 23 May 2008 Revisions received 19 Jun 2008 Accepted 1 Aug 2008 Published 1 Aug 2008 Arthritis Research Therapy 2008 10 R86 doi ar2466 This article is online at http content 10 4 R86 2008 Jones et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Apoptosis has been reported to occur in the intervertebral disc. Elsewhere in the body apoptotic cells are cleared from the system via phagocytosis by committed phagocytes such as macrophages reducing the chance of subsequent inflammation. These cells however are not normally present in the disc. We investigated whether disc cells themselves can be induced to become phagocytic and so have the ability to ingest and remove apoptotic disc cells minimising the damage to their environment. Method Bovine nucleus pulposus cells from caudal intervertebral discs were grown in culture and exposed to both latex particles which are ingested by committed phagocytes and apoptotic cells. Their response was monitored via microscopy including both fluorescent and video microscopy and compared with that seen by cell lines of monocytes macrophages THP-1 and
