Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation: therapeutic implications. | Available online http content 10 4 115 Editorial Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation therapeutic implications Manolis Heliotis1 and Eleftherios Tsiridis2 1 Regional North West London Maxillofacial Unit Northwick Park Hospital Wattford Road Harrow London HA1 3UJ UK 2Academic Orthopaedic Unit Institute of Molecular Medicine Leeds Medical School and Leeds General Infirmary Teaching Hospital Clarendon Great George Street Leeds LS1 3EX UK Corresponding author Eleftherios Tsiridis etsiridis@ Published 12 August 2008 Arthritis Research Therapy 2008 10 115 doi ar2467 This article is online at http content 10 4 115 2008 BioMed Central Ltd See related research article by Kwong et al. http content 10 3 R65 Abstract Bone morphogenetic proteins BMPs are expressed during osteogenesis and their action is regulated by corresponding BMP inhibitors. Chordin a well recognized BMP inhibitor and BMP-2 are expressed during osteogenic differentiation of human mesenchymal stem cells. Chordin inhibition induces human mesenchymal stem cell differentiation and reduces their proliferation by increasing BMP-2 bioavailability. The potential of suppressing BMP inhibitors is emerging as a biological therapeutic target in bone tissue engineering because it results in an unopposed synergy between the various growth factors that are involved in osteogenesis within their physiological milieu. Bone morphogenetic proteins BMPs a distinct transforming growth factor TGF -p subgroup that is also involved in organogenesis have been shown to be expressed during various stages of bone healing process. Mesenchymal stem cells MSCs that are capable of differentiation toward the osteogenic lineage are recruited from local deposits or the circulation to initiate callous formation. Kwong and coworkers 1 in their recent report presented the expression of BMP-2 and its .
