Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration. | Available online http content 10 4 R87 Research article Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration Sarah Kathleen Heathfield1 Christine Lyn Le Maitre2 and Judith Alison Hoyland1 Tissue Injury and Repair Group Research School of Clinical and Laboratory Sciences Faculty of Medical and Human Sciences Stopford Building The University of Manchester Oxford Road Manchester M13 9PT UK 2Biomedical Research Centre Biosciences Faculty of Health and Wellbeing Sheffield Hallam University City Campus Howard Street Sheffield S1 1WB UK Corresponding author Judith Alison Hoyland Received 20 May 2008 Revisions requested 1 2 Jun 2008 Revisions received 9 Jul 2008 Accepted 5 Aug 2008 Published 5 Aug 2008 Arthritis Research Therapy 2008 10 R87 doi ar2468 This article is online at http content 10 4 R87 2008 Heathfield et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Chronic and debilitating low back pain is a common condition and a huge economic burden. Many cases are attributed to age-related degeneration of the intervertebral disc IVD however age-related degeneration appears to occur at an accelerated rate in some individuals. We have previously demonstrated biomarkers of cellular senescence within the human IVD and suggested a role for senescence in IVD degeneration. Senescence occurs with ageing but can also occur prematurely in response to stress. We hypothesised that stress-induced premature senescence SIPS occurs within the IVD and here we have investigated the expression and production of caveolin-1 a protein that has been shown previously to be .
