Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis. | Available online http content 10 4 213 Review Altered lipoprotein metabolism in chronic inflammatory states proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis Bevra H Hahn Jennifer Grossman Benjamin J Ansell Brian J Skaggs and Maureen McMahon Divisions of Rheumatology and Cardiology David Geffen School of Medicine at University of California Los Angeles 1000 Veteran Avenue Los Angeles CA 90095 USA Corresponding author Bevra H Hahn bhahn@ Published 29 August 2008 This article is online at http content 10 4 213 2008 BioMed Central Ltd Arthritis Research Therapy 2008 10 213 doi ar2471 Abstract In this review the authors discuss the formation and structure of high-density lipoproteins HDLs and how those particles are altered in inflammatory or stress states to lose their capacity for reverse cholesterol transport and for antioxidant activity. In addition abnormal HDLs can become proinflammatory piHDLs and actually contribute to oxidative damage. The assay by which piHDLs are identified involves studying the ability of test HDLs to prevent oxidation of low-density lipoproteins. Finally the authors discuss the potential role of piHDLs found in some 45 of patients with systemic lupus erythematosus and 20 of patients with rheumatoid arthritis in the accelerated atherosclerosis associated with some chronic rheumatic diseases. Overview of the pathogenesis of atherosclerosis Multiple factors play a role in the development of clinical atherosclerosis including lipids inflammation physical sheer forces and aging. This review is concerned with the role of high-density lipoproteins HDLs in both protecting and promoting atherosclerosis. In quick review then low-density lipoproteins LDLs shuttle in and out of artery walls when they are minimally or moderately oxidized within the wall oxLDLs they become proinflammatory. Endothelial cells
