Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis. | Available online http content 10 4 R90 Research article Role of fibroblast growth factor 8 FGF8 in animal models of osteoarthritis Masako Uchii1 Tadafumi Tamura1 Toshio Suda1 Masakazu Kakuni1 2 Akira Tanaka3 and Ichiro Miki1 Pharmaceutical Research Center Kyowa Hakko Kogyo Co. Ltd 1188 Shimotogari Nagaizumi Sunto Shizuoka 411-8731 Japan 2Present address PhoenixBio Co. Ltd 3-4-1 Kagamiyama Higashi-Hiroshima Hiroshima 739-0046 Japan 3Department of Pathology Jichi Medical University 3311-1 Yakushiji Shimotsuke Tochigi 329-0498 Japan Corresponding author Ichiro Miki Received 13 May 2008 Revisions requested 26 Jun 2008 Revisions received 22 Jul 2008 Accepted 1 2 Aug 2008 Published 1 2 Aug 2008 Arthritis Research Therapy 2008 10 R90 doi ar2474 This article is online at http content 10 4 R90 2008 Uchii et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Fibroblast growth factor 8 FGF8 is isolated as an androgen-induced growth factor and has recently been shown to contribute to limb morphogenesis. The aim of the present study was to clarify the role of FGF8 in animal models of osteoarthritis OA . Methods The expression of FGF8 in the partial meniscectomy model of OA in the rabbit knee was examined by immunohistochemistry. The effect of intraperitoneal administration of anti-FGF8 antibody was tested in a model of OA that employed injection of monoiodoacetic acid or FGF8 into the knee joint of rats. The effect of FGF8 was also tested using cultured chondrocytes. Rabbit articular chondrocytes were treated with FGF8 for 48 hours and the production of matrix metalloproteinase and the degradation of sulfated .
