Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cia5d regulates a new fibroblast-like synoviocyte invasion-associated gene expression signature. | Available online http content 10 4 R92 Research article Cia5d regulates a new fibroblast-like synoviocyte invasion-associated gene expression signature Teresina Laragione1 Max Brenner1 Wentian Li2 and Pércio S Gulko1 3 Open Access Laboratory of Experimental Rheumatology Center for Genomics and Human Genetics Feinstein Institute for Medical Research 350 Community Drive Manhasset New York 11030 USA 2Genomics and Human Genetics Feinstein Institute for Medical Research 350 Community Drive Manhasset New York 11 030 USA 3Department of Medicine New York University School of Medicine 550 First Avenue New York 1001 6 USA Corresponding author Pércio S Gulko pgulko@ Received 18 Apr 2008 Revisions requested 21 May 2008 Revisions received 17 Jul 2008 Accepted 15 Aug 2008 Published 15 Aug 2008 Arthritis Research Therapy 2008 10 R92 doi ar2476 This article is online at http content 10 4 R92 2008 Laragione et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The in vitro invasive properties of rheumatoid arthritis RA fibroblast-like synoviocytes FLSs have been shown to correlate with disease severity and radiographic damage. We recently determined that FLSs obtained from pristane-induced arthritis PIA -susceptible DA rats are also highly invasive in the same in vitro assay through Matrigel. The transfer of alleles derived from the arthritis-resistant F344 strain at the arthritis severity locus Cia5d RNO10 as in Cia5d congenics was enough to significantly and specifically reduce the invasive properties of FLSs. This genetically controlled difference in FLS invasion involves increased production of soluble membrane-type 1 matrix metalloproteinase .
