Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc. | Available online http content 10 4 R96 Research article Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc Helen E Gruber1 Paul Bornstein2 E Helene Sage3 Jane A Ingram1 Natalia Zinchenko1 H James Norton4 and Edward N Hanley Jr1 Department of Orthopaedic Surgery Carolinas Medical Center PO Box 32861 Charlotte NC 28232 USA departments of Medicine and Biochemistry University of Washington Seattle WA 98195 USA 3Hope Heart Program The Benaroya Institute at Virginia Mason 1201 Ninth Avenue Seattle WA 98101 -2795 USA department of Biostatistics Carolinas Medical Center PO Box 332861 Charlotte NC 28232 USA Corresponding author Helen E Gruber Received 22 May 2008 Revisions requested 11 Jul 2008 Revisions received 1 Aug 2008 Accepted 21 Aug 2008 Published 21 Aug 2008 Arthritis Research Therapy 2008 10 R96 doi ar2483 This article is online at http content 10 4 R96 2008 Gruber et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The biological basis for the avascular state of the intervertebral disc is not well understood. Previous work has suggested that the presence of thrombospondin-1 TSP-1 a matricellular protein in the outer annulus reflects a role for this protein in conferring an avascular status to the disc. In the present study we have examined thrombospondin-2 TSP-2 a matricellular protein with recognized anti-angiogenic activity in vivo and in vitro. Methods We examined both the location and expression of TSP-2 in the human disc and its location in the disc and bordering soft tissues of 5-month-old normal wild-type
