Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: What magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis - the first 50 years. | Available online http content 10 5 222 Review What magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis - the first 50 years Dennis McGonagle and Ai Lyn Tan Academic Unit of Musculoskeletal Disease University of Leeds and Chapel Allerton Hospital Chapeltown Road Leeds LS7 4SA UK Corresponding author Dennis McGonagle Published 10 October 2008 This article is online at http content 10 5 222 2008 BioMed Central Ltd Arthritis Research Therapy 2008 10 222 doi ar2512 Abstract Modern imaging modalities including magnetic resonance imaging MRI are valuable diagnostic and therapy monitoring tools in rheumatoid arthritis RA . This article reviewed how these imaging modalities have greatly improved our understanding of pathogenic mechanisms in RA namely the link between inflammation and damage. For example traditional paradigms regarding the mechanisms of joint destruction including the idea that synovitis and damage are uncoupled have been challenged. As the power of MRI increases there is a need to define normality since apparently normal joints occasionally exhibit MRI evidence of synovitis in the absence of symptoms. Introduction a historical perspective Historically subjects with rheumatoid arthritis RA presented relatively late for specialist rheumatology assessment following the failure of anti-inflammatory agents. Patients were eventually treated with disease-modifying therapies such as gold and penicillamine which were of limited efficacy in comparison with modern therapeutic standards. Taken together this delayed presentation and relative inefficacy of therapies meant that many patients had quite florid joint destruction at clinical presentation. The gold standard clinical imaging modality for RA is projection radiography x-ray in which periarticular osteopenia joint space loss and marginal erosion are noted to be commonplace. Of these abnormalities .
