Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Vascular involvement in rheumatic diseases: ‘vascular rheumatology’. | Available online http content 10 5 224 Review Vascular involvement in rheumatic diseases vascular rheumatology Zoltán Szekaneez1 and Alisa E Koch2 3 1 University of Debrecen Medical Center Institute of Medicine Department of Rheumatology 22 Moricz street Debrecen H-4032 Hungary 2Veterans Administration Ann Arbor Healthcare System 2215 Fuller Road Ann Arbor MI 48105 USA 3University of Michigan Health System Division of Rheumatology Department of Internal Medicine University of Michigan Medical School 109 Zina Pitcher Place Ann Arbor MI 48109-2200 USA Corresponding author Zoltán Szekanecz szekanecz@ Published 10 October 2008 This article is online at http content 10 5 224 2008 BioMed Central Ltd Arthritis Research Therapy 2008 10 224 doi ar2515 Abstract The vasculature plays a crucial role in inflammation angiogenesis and atherosclerosis associated with the pathogenesis of inflammatory rheumatic diseases hence the term vascular rheumatology . The endothelium lining the blood vessels becomes activated during the inflammatory process resulting in the production of several mediators the expression of endothelial adhesion molecules and increased vascular permeability leakage . All of this enables the extravasation of inflammatory cells into the interstitial matrix. The endothelial adhesion and transendothelial migration of leukocytes is a well-regulated sequence of events that involves many adhesion molecules and chemokines. Primarily selectins integrins and members of the immunoglobulin family of adhesion receptors are involved in leukocyte tethering rolling activation and transmigration. There is a perpetuation of angiogenesis the formation of new capillaries from pre-existing vessels as well as that of vasculogenesis the generation of new blood vessels in arthritis and connective tissue diseases. Several soluble and cell-bound angiogenic mediators produced mainly by monocytes macro-phages and endothelial .
