Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis. | Available online http content 10 5 R117 Research article Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis Teresia M Osborn1 2 Margareta Verdrengh1 Thomas P Stossel2 Andrej TarkowskiA1 and Maria Bokarewa1 Department of Rheumatology and Inflammation Research University of Gothenburg Guldhedsgatan 10A S-413 46 Gothenburg Sweden 2Translational Medicine Division Brigham and Women s Hospital Department of Medicine Harvard Medical School 75 Francis Street Boston MA 02115 USA Corresponding author Teresia M Osborn tmagnuson@ ADeceased Received 19 Jun 2007 Revisions requested 1 Aug 2007 Revisions received 1 Sep 2008 Accepted 27 Sep 2008 Published 27 Sep 2008 Arthritis Research Therapy 2008 10 R11 7 doi 86 ar2520 This article is online at http content 10 5 R117 2008 Osborn et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Gelsolin is an intracellular actin-binding protein involved in cell shape changes cell motility and apoptosis. An extracellular gelsolin isoform plasma gelsolin circulates in the blood of healthy individuals at a concentration of 200 50 mg L and has been suggested to be a key component of an extracellular actin-scavenging system during tissue damage. Levels of plasma gelsolin decrease during acute injury and inflammation and administration of recombinant plasma gelsolin to animals improves outcomes following sepsis or burn injuries. In the present study we investigated plasma gelsolin in patients with rheumatoid arthritis. Methods Circulating and intra-articular levels of plasma gelsolin were measured in 78 patients with rheumatoid arthritis using a functional .
