Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Serum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine. | Available online http content 10 5 120 Editorial Serum urate menopause and postmenopausal hormone use from eminence to evidence-based medicine Angelo L Gaffo1 and Kenneth G Saag2 1 Birmingham VA Medical Center 700 19th Street South Birmingham AL 35233 USA 2Division of Clinical Immunology and Rheumatology University of Alabama at Birmingham FOT 820 1530 3rd Avenue South Birmingham AL 35294 USA Corresponding author Kenneth G Saag ksaag@ Published 17 October 2008 Arthritis Research Therapy 2008 10 120 doi ar2524 This article is online at http content 10 5 120 2008 BioMed Central Ltd See related research article by Hak and Choi http content 10 5 R116 Abstract The relationship between serum urate menopause and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy Hak and Choi present a crosssectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the Third National Health and Nutritional Examination Survey. Menopause increased serum urate and hormone replacement therapy significantly decreased serum urate although the overall level of change was small. The implications of these urate changes on gout and cardiovascular disease outcomes require further study. In the past era of predominately opinion-based or eminencebased medicine the relationship between serum urate sex and aging has always been perceived by astute clinicians to be a rather simple one namely women have lower levels of serum urate than men and have a lower prevalence of gout. In women serum urate levels increase with aging and the onset of menopause until the levels roughly equal those of men in later years - this is the traditional view being revised in the present issue of Arthritis Research and Therapy by Hak and Choi s study 1 . Menopause and hormone replacement therapies possibly mediated by steroid
