Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis. | Available online http content 10 6 R135 Research article Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis Francesco Ria1 Romina Penitente1 2 Maria De Santis2 Chiara Nicolò1 Gabriele Di Sante1 Massimiliano Orsini3 Dario Arzani3 Andrea Fattorossi4 Alessandra Battaglia4 and Gian Franco Ferraccioli1 Open Access institute of General Pathology Catholic University Largo F Vito Rome 00168 Italy 2Department of Rheumatology Catholic University CIC Via Moscati Rome 00168 Italy institute of Hygiene and Biostatistics Catholic University Largo F Vito Rome 00168 Italy 4Department of Gynecology Laboratory of Immunology Catholic University Largo F Vito Rome 00168 Italy Contributed equally Corresponding author Francesco Ria fria@ Franco Ferraccioli Received 1 2 May 2008 Revisions requested 27 Jun 2008 Revisions received 28 Oct 2008 Accepted 17 Nov 2008 Published 17 Nov 2008 Arthritis Research Therapy 2008 10 R135 doi 86 ar2553 This article is online at http content 10 6 R135 2008 Ria et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Type II collagen is a DR4 DR1 restricted target of self-reactive T cells that sustain rheumatoid arthritis. The aim of the present study was to analyze the T-cell receptor repertoire at the onset of and at different phases in rheumatoid arthritis. Methods We used the CDR3 BV-BJ spectratyping to study the response to human collagen peptide 261-273 in 12 patients with DR4 rheumatoid arthritis six at the onset of disease and six during the course of disease and in five healthy DR4 relatives. Results The collagen-specific
