Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis. | Available online http content 10 6 R136 Research article T-614 a novel immunomodulator attenuates joint inflammation and articular damage in collagen-induced arthritis Fang Du Liang-jing Lu Qiong Fu Min Dai Jia-lin Teng Wei Fan Shun-le Chen Ping Ye Nan Shen Xin-fang Huang Jie Qian and Chun-de Bao Open Access Shanghai Institute of Rheumatology Renji Hospital Shanghai Jiao Tong University School of Medicine Shan Dong Middle Road Shanghai 200001 PR China Corresponding author Chun-de Bao bao_cd@ Received 2 Sep 2008 Revisions requested 9 Oct 2008 Revisions received 29 Oct 2008 Accepted 19 Nov 2008 Published 19 Nov 2008 Arthritis Research Therapy 2008 10 R136 doi 86 ar2554 This article is online at http content 10 6 R136 2008 Du et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction T-614 is a novel oral antirheumatic agent for the treatment of rheumatoid arthritis. Whether it has immunomodulatory or disease-modifying properties and its mechanism of action are largely undetermined. Methods Rats with collagen-induced arthritis CIA were treated with T-614 5 and 20 mg kg daily. Animals receiving methotrexate 1 mg kg every 3 days and the nonsteroidal anti-inflammatory agent nimesulide 10 mg kg per day were used as controls. A combination therapy group was treated with both T-614 10 mg kg per day and methotrexate 1 mg kg every 3 days . Hind paw swelling was evaluated and radiographic scores calculated. Serum cytokine levels were assessed by Bio-plex analysis. Quantitative PCR was used to evaluate expression of mRNA for interferon-Ỵ IL-4 and IL-17. Serum IL-17 and anti-type II collagen antibodies total IgG IgG1 IgG2a IgG2b and IgM were measured using .
