Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression. | Available online http content 10 6 R139 Research article Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression Peter S Burrage1 Adam C Schmucker1 Yanqing Ren1 Michael B Sporn2 and Constance E Brinckerhoff1 3 Department of Biochemistry Dartmouth Medical School North College Street 7200 Vail Building Hanover NH 03755 USA 2Department of Pharmacology Dartmouth Medical School North College Street 7650 Remsen Hall Hanover NH 03755 USA 3Department of Medicine Dartmouth Medical School 1 Medical Center Drive Lebanon NH 03756 USA Contributed equally Corresponding author Constance E Brinckerhoff brinckerhoff@ Received 8 Sep 2008 Revisions requested 9 Oct 2008 Revisions received 6 Nov 2008 Accepted 1 Dec 2008 Published 1 Dec 2008 Arthritis Research Therapy 2008 10 R139 doi 86 ar2564 This article is online at http content 10 6 R139 2008 Burrage et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction We recently described the ability of retinoid X receptor RXR ligand LG100268 LG268 to inhibit interleukin-1-beta IL-1-p -driven matrix metalloproteinase-1 MMP-T and MMP-13 gene expression in SW-1353 chondrosarcoma cells. Other investigators have demonstrated similar effects in chondrocytes treated with rosiglitazone a ligand for peroxisome proliferator-activated receptor-gamma PPARy for which RXR is an obligate dimerization partner. The goals of this study were to evaluate the inhibition of IL-1-p-induced expression of MMP-1 and MMP-13 by combinatorial treatment with RXR and PPARy ligands and to investigate the molecular mechanisms of this inhibition. .
