Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The differential expressions of 78-kDa glucose-regulated protein of infiltrating plasma cells in peripheral joints with the histopathological variants of rheumatoid synovitis. | Available online http content 11 1 R4 Research article The differential expressions of 78-kDa glucose-regulated protein of infiltrating plasma cells in peripheral joints with the histopathological variants of rheumatoid synovitis Weijia Dong1 2 Xiaoyan Li1 Yuan Feng1 Chunmei Fan1 Zhinan Chen2 and Ping Zhu1 1 Department of Clinical Immunology State Key Discipline of Cell Biology Xijing Hospital Fourth Military Medical University 1 7 Changlexi Street Xi an 710032 Shaanxi PR China 2Cell Engineering Research Center State Key Discipline of Cell Biology Fourth Military Medical University 1 7 Changlexi Street Xi an 710032 Shaanxi PR China Corresponding author Zhinan Chen chcerc2@ Zhu zhuping@ Received 22 Jul 2008 Revisions requested 5 Sep 2008 Revisions received 30 Nov 2008 Accepted 9 Jan 2009 Published 9 Jan 2009 Arthritis Research Therapy 2009 11 R4 doi 1 ar2588 This article is online at http content 11 1 R4 2009 Dong et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The local production of pathogenic autoantibodies by plasma cells in synovium is one of the hallmarks of rheumatoid arthritis RA . There may be a potential link between ectopic lymphoid neogenesis and the local autoimmunity in rheumatoid synovium. The unfolded protein response UPR has key roles in the development and maintenance of plasma cells secreting immunoglobulin. This study was designed to explore the potential links between the activation of the UPR of infiltrating plasma cells in inflamed peripheral joints and the histopathological variants of rheumatoid synovitis as well as the local production of pathogenic autoantibodies. Methods The .
