Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study. | Available online http content 11 2 R35 Research article Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult a longitudinal experimental study Janny C de Grauw1 Chris HA van de Lest2 and Paul René van Weeren1 1 Department of Equine Sciences Faculty of Veterinary Medicine Utrecht University Yalelaan 114 3584 CM Utrecht The Netherlands 2Department of Biochemistry and Cell Biology Faculty of Veterinary Medicine Utrecht University Yalelaan 2 3584 CM Utrecht The Netherlands Corresponding author Janny C de Grauw Received 5 Dec 2008 Revisions requested 18 Jan 2009 Revisions received 16 Feb 2009 Accepted 9 Mar 2009 Published 9 Mar 2009 Arthritis Research Therapy 2009 11 R35 doi ar2640 This article is online at http content 11 2 R35 2009 de Grauw et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Inflammation is an important feature of many joint diseases and levels of cartilage biomarkers measured in synovial fluid may be influenced by local inflammatory status. Little is known about the magnitude and time course of inflammation-induced changes in cartilage tissue turnover as measured in vivo by synovial fluid markers. We aimed to study temporal changes in concentrations of inflammatory mediators matrix metalloproteinase activity and cartilage biomarkers over 1 week in joints with experimentally induced inflammation. Methods Localized inflammation was induced in the intercarpal joint of six horses by sterile injection of ng lipopolysaccharide and synovial fluid was collected at postinjection hours PIH 0 8 24 and 168. Concentrations of inflammatory mediators prostaglandin .
