Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The changing landscape of the clinical value of the PM/Scl autoantibody system. | Available online http content 11 2 106 Editorial The changing landscape of the clinical value of the PM Scl autoantibody system Michael Mahler1 and Marvin J Fritzler2 1Dr Fooke Laboratorien GmbH Mainstr. 41469 Neuss Germany 2Faculty of Medicine University of Calgary Hospital Dr NW Calgary Alberta Canada T2N 4N1 Both authors contributed equally Corresponding author Marvin J Fritzler fritzler@. Published 26 March 2009 Arthritis Research Therapy 2009 11 106 doi ar2646 This article is online at http content 11 2 106 2009 BioMed Central Ltd See related research article by Hanke et al. http content 11 1 R22 Abstract Autoantibodies to the polymyositis scleroderma PM Scl complex have been associated with systemic sclerosis and PM Scl overlap syndrome. The report of Hanke and colleagues in a recent issue of Arthritis Research and Therapy is the first to describe the separate evaluation of anti-PM Scl-75c and PM Scl-100 autoantibodies and their relationship to clinical manifestations of systemic sclerosis. Several observations are of paramount interest but are not in general agreement with earlier studies. These include the prevalence of anti-PM Scl antibodies in systemic sclerosis the association with certain clinical manifestations and prognosis of patients. This report will hopefully trigger systematic multi-centre studies to confirm and or elucidate the novel line immunoassay and clinical associations. Background A characteristic feature of patients with systemic sclerosis SSc or scleroderma Scl are anti-nucleolar antibodies ANoAs including autoantibodies aabs to components of the exosome known also as the polymyositis scleroderma PM Scl complex 1 2 . While the majority of the anti-PM Scl reactivity is directed against PM Scl-TSc and PM Scl-100 many of the other nine core exosome components are also targeted albeit with lower frequency and apparently limited diagnostic value 2 . .
