Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Microparticle-induced release of B-lymphocyte regulators by rheumatoid synoviocytes. | Available online http content 11 2 R40 Research article Microparticle-induced release of B-lymphocyte regulators by rheumatoid synoviocytes Laurent Messer1 2 Ghada Alsaleh1 2 Jean-Marie Freyssinet3 4 Fatiha Zobairi3 4 Isabelle Leray1 2 Jacques-Eric Gottenberg1 2 Jean Sibilia1 2 Florence Toti-Orfanoudakis3 4 and Dominique Wachsmann1 2 1Laboratoire Physiopathologie des Arthrites Université de Strasbourg UFR Sciences Pharmaceutiques 74 route du Rhin Illkirch 67401 France 2Département de Rhumatologie Hôpitaux Universitaires de Strasbourg Avenue Molière Strasbourg Hautepierre 67200 France 3Laboratoire de Biologie Cellulaire et Vasculaire Faculté de Médecine 4 rue Kirschleger Strasbourg 67085 France 4Inserm U770 Hôpital Bicêtre AP-HP 78 rue du Général Leclerc Le Kremlin-Bicêtre 94275 France Corresponding author Dominique Wachsmann Received 23 Feb 2009 Accepted 16 Mar 2009 Published 16 Mar 2009 Arthritis Research Therapy 2009 11 R40 doi ar2648 This article is online at http content 11 2 R40 2009 Messer et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction In the present study we investigated the ability of microparticles isolated from synovial fluids from patients with rheumatoid arthritis or osteoarthritis to induce the synthesis and release of key cytokines of B-lymphocyte modulation such as B cell-activating factor thymic stroma lymphopoietin and secretory leukocyte protease inhibitor by rheumatoid fibroblastlike synoviocytes. Methods Microparticles were analyzed in synovial fluids from patients with rheumatoid arthritis osteoarthritis microcristalline arthritis and reactive arthritis. In addition .
