Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis. | Available online http content 11 2 R44 Research article Human articular chondrocytes express 15-lipoxygenase-1 and -2 potential role in osteoarthritis Nadir Chabane1 2 Nadia Zayed1 2 Mohamed Benderdour3 Johanne Martel-Pelletier1 2 Jean-Pierre Pelletier1 2 Nicolas Duval4 and Hassan Fahmi1 2 Osteoarthritis Research Unit Research Centre of the University of Montreal Hospital Center CR-CHUM Notre-Dame Hospital Sherbrooke Street East Montreal Quebec H2L 4M1 Canada 2Department of Medicine University of Montreal Montreal Quebec H2L 4M1 Canada 3Research Centre Sacré-Coeur Hospital Gouin Boulevard West Montreal Quebec H4J 1C5 Canada 4Centre de Convalescence de Charmilles Pavillion des Laurentides Boulevard Montreal Quebec H7M 2Y3 Canada Corresponding author Hassan Fahmi Received 12 Nov 2008 Revisions requested 23 Dec 2008 Revisions received 4 Mar 2009 Accepted 18 Mar 2009 Published 18 Mar 2009 Arthritis Research Therapy 2009 11 R44 doi ar2652 This article is online at http content 11 2 R44 2009 Chabane et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction 15-Lipoxygenases and their metabolites have been shown to exhibit anti-inflammatory and immunomodulatory properties but little is known regarding their expression and function in chondrocytes. The objective of this study was to evaluate the expression of 15-lipoxygenase-1 and -2 in human articular chondrocytes and to investigate the effects of their metabolites 13 S -hydroxy octadecadienoic and 15 S -hydroxyeicosatetraenoic acids on IL-1 p-induced matrix metalloproteinase MMP -1 and MMP-13 expression. Methods The expression levels of 15-lipoxygenase-1 and -2 were analyzed .
