Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway. | Available online http content 11 2 R48 Open Access Research article Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1 2 dependent pathway Herng-Sheng Lee1 Chung-Shinn Lee2 Chi-Jung Yang2 Sui-Long Su3 and Donald M Salter4 Department of Pathology Tri-Service General Hospital and National Defense Medical Center No. 325 Sec. 2 Chenggong Rd Neihu District Taipei City 114 Taiwan 2Graduate Institute of Pathology and Parasitology National Defense Medical Center No. 161 Minchun E. Rd Neihu District Taipei City 11 4 Taiwan 3School of Public Health National Defense Medical Center No. 161 Minchun E. Rd Neihu District Taipei City 114 Taiwan 4Osteoarticular Research Group Centre for Inflammation Research Queens Medical Research Institute 47 Little France Crescent Edinburgh EH16 4TJ UK Corresponding author Herng-Sheng Lee herngsheng131419@ Received 19 Sep 2008 Revisions requested 6 Nov 2008 Revisions received 1 7 Mar 2009 Accepted 29 Mar 2009 Published 29 Mar 2009 Arthritis Research Therapy 2009 11 R48 doi ar2661 This article is online at http content 11 2 R48 2009 Lee et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Synovial cells are potential sources of inflammatory mediators in bacterial-induced arthritis but their involvement in the inflammatory response to Candida albicans-induced septic arthritis is largely unknown. Methods Primary cultures of rat synovial fibroblasts were infected with C. albicans ATCC90028 . Immunocytochemistry western blotting and RT-PCR were performed to assess cyclooxygenase 2 induction. Phosphorylation of .
