Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Inflammation predicts accelerated brachial arterial wall changes in patients with recent-onset rheumatoid arthritis. | Available online http content 11 2 R51 Research article Inflammation predicts accelerated brachial arterial wall changes in patients with recent-onset rheumatoid arthritis Suad Hannawi1 Thomas H Marwick2 and Ranjeny Thomas1 1Diamantina Institute University of Queensland Princess Alexandra Hospital Ipswich Road Woolloongabba Queensland 4102 Australia 2Department of Medicine University of Queensland Princess Alexandra Hospital Ipswich Road Woolloongabba Queensland 4102 Australia Contributed equally Corresponding author Ranjeny Thomas Received 17 Dec 2008 Revisions requested 14 Jan 2009 Revisions received 16 Mar 2009 Accepted 6 Apr 2009 Published 6 Apr 2009 Arthritis Research Therapy 2009 11 R51 doi ar2668 This article is online at http content 11 2 R51 2009 Hannawi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Patients with recent-onset rheumatoid arthritis RA have impaired brachial artery endothelial function compared with controls matched for age sex and cardiovascular risk factors. The present study examined endothelium-dependent flow-mediated dilatation FMD and independent glyceryl trinitrate GTN -mediated dilatation GMD structural responses in early RA patients and determined progress over one year. Methods Brachial artery FMD and GMD and carotid intima media thickness cIMT were studied using ultrasound in 20 patients diagnosed with early RA in whom symptoms had been present for less than 12 months and in 20 control subjects matched for age sex and established cardiovascular risk factors. FMD and GMD were re-assessed after 12 months in RA patients and the change in each parameter was calculated. Data were
