Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Class-switched B cells display response to therapeutic B-cell depletion in rheumatoid arthritis. | Available online http content 11 3 R62 Research article Class-switched B cells display response to therapeutic B-cell depletion in rheumatoid arthritis Burkhard Moller1 Daniel Aeberli1 Stefan Eggli2 Martin Fuhrer1 Istvan Vajtai3 Esther Vogelin4 Hans-Rudolf Ziswiler1 Clemens A Dahinden5 and Peter M Villiger1 1Clinic for Rheumatology Clinical Immunology and Allergology Inselspital - University Hospital of Bern FreiburgstraBe Bern 3010 Switzerland department of Orthopaedic Surgery Inselspital - University Hospital of Bern FreiburgstraBe Bern 3010 Switzerland 3Section of Neuropathology Institute of Pathology University of Bern MurtenstraBe 31 Bern 3010 Switzerland department of Orthopaedic Plastic and Reconstructive and Hand Surgery Inselspital - University Hospital of Bern FreiburgstraBe Bern 3010 Switzerland institute of Immunology Inselspital - University Hospital of Bern FreiburgstraBe Bern 3010 Switzerland Corresponding author Burkhard Moller Received 28 Nov 2008 Revisions requested 13 Jan 2009 Revisions received 10 Mar 2009 Accepted 6 May 2009 Published 6 May 2009 Arthritis Research Therapy 2009 11 R62 doi ar2686 This article is online at http content 11 3 R62 2009 Moller et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Reconstitution of peripheral blood PB B cells after therapeutic depletion with the chimeric anti-CD20 antibody rituximab RTX mimics lymphatic ontogeny. In this situation the repletion kinetics and migratory properties of distinct developmental B-cell stages and their correlation to disease activity might facilitate our understanding of innate and adaptive B-cell functions in rheumatoid .
