Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts. | Available online http content 11 3 R68 Research article Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts Mária Pásztói1 Gyorgy Nagy2 Pál Géher2 Tamás Lakatos2 Kálmán Tóth3 Károly Wellinger3 Péter Pocza1 Bence Gyorgy1 Marianna C Holub1 Ágnes Kittel4 Krisztina Pálóczy1 Mercédesz Mazán1 Péter Nyirkos1 András Falus1 5 and Edit I Buzas1 department of Genetics Cell and Immunobiology Semmelweis University Nagyvárad tér 4 Budapest H-1089 Hungary department of Rheumatology Semmelweis University Frankel Leó utca 54 Budapest H-1027 Hungary department of Orthopedic Surgery Szeged University Semmelweis Szeged H-6725 Hungary 4Institute of Experimental Medicine Hungarian Academy of Sciences Szigony u. 43 Budapest H-1083 Hungary inflammation Biology and Immunogenomics Research Group Hungarian Academy of Sciences-Semmelweis University Nagyvárad tér 4 Budapest H-1089 Hungary Corresponding author Edit I Buzas Received 14 Nov 2008 Revisions requested 18 Dec 2008 Revisions received 9 Mar 2009 Accepted 14 May 2009 Published 14 May 2009 Arthritis Research Therapy 2009 11 R68 doi ar2697 This article is online at http content 11 3 R68 2009 Pásztói et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Similar to matrix metalloproteinases glycosidases also play a major role in cartilage degradation. Carbohydrate cleavage products generated by these latter enzymes are released from degrading cartilage during arthritis. Some of the cleavage products such as hyaluronate oligosaccharides have been shown to bind to Toll-like receptors and provide endogenous .
