Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls. | Available online http content 11 3 R70 Research article Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls Klaus Stark1 Jozef Rovenský2 Stanislava Blazickova2 Hans Grosse-Wilde3 Stanislav Ferencik3 Christian Hengstenberg1 and Rainer H Straub4 Open Access Department of Internal Medicine II University Hospital Regensburg Franz-Josef-Strauss-Allee 11 93042 Regensburg Germany 2National Institute of Rheumatic Diseases Nabr. I. Krasku 4 921 23 Piest any Slovakia institute of Immunology University Hospital of Essen Virchowstrasse 1 79 45122 Essen Germany department of Internal Medicine I University Hospital Regensburg Franz-Josef-Strauss-Allee 11 93042 Regensburg Germany Corresponding author Rainer H Straub Received 31 Jan 2009 Revisions requested 31 Mar 2009 Revisions received 8 Apr 2009 Accepted 15 May 2009 Published 15 May 2009 Arthritis Research Therapy 2009 11 R70 doi ar2699 This article is online at http content 11 3 R70 2009 Stark et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Both genetic and environmental factors contribute to rheumatoid arthritis RA a common and complex autoimmune disease. As well as the major susceptibility gene HLA-DRB1 recent genome-wide and candidate-gene studies reported additional evidence for association of single nucleotide polymorphism SNP markers in the PTPN22 STAT4 OLIG3 TNFAIP3 and TRAF1 C5 loci with RA. This study was initiated to investigate the association between defined genetic markers and RA in a Slovak population. In contrast to recent studies we included .