Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies. | Available online http content 11 3 R77 Research article Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies Corinne Miceli-Richard1 2 Nicolas Gestermann2 Corinne Amiel3 Jeremie Sellam1 2 Marc Ittah2 Stephan Pavy1 Alejandra Urrutia2 Isabelle Girauld2 Guislaine Carcelain4 Alain Venet2 and Xavier Mariette1 2 Open Access 1Rhumatologie Hôpital Bicêtre Assistance Publique-Hôpitaux de Paris AP-HP 78 rue du General Leclerc 94275 Le Kremlin Bicêtre France 2Institut Pour la Santé et la Recherche Médicale INSERM U 802 Université Paris-Sud 11 64 rue Gabriel Peri 94275 Le Kremlin Bicêtre France 3Virologie Hôpital Tenon AP-HP 4 rue de la Chine 75020 Paris France 4INSERM U543 Hôpital La Pitie Salpètrière AP-HP 47 Boulevard de l Hôpital 75013 Paris France Contributed equally Corresponding author Xavier Mariette Received 24 Dec 2008 Revisions requested 17 Feb 2009 Revisions received 31 Mar 2009 Accepted 26 May 2009 Published 26 May 2009 Arthritis Research Therapy 2009 11 R77 doi ar2708 This article is online at http content 11 3 R77 2009 Miceli-Richard et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction There is a suspicion of increased risk of Epstein-Barr virus EBV -associated lymphoproliferations in patients with inflammatory arthritides receiving immunosuppressive drugs. We investigated the EBV load and EBV-specific T-cell response in patients treated with methotrexate MTX or anti-TnF therapy. Methods Data for patients with rheumatoid arthritis RA n 58 or spondylarthropathy SpA n 28 were analyzed at baseline in comparison with .
