Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis. | Available online http content 11 3 R82 Research article Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis Christian Barthel1 Nataliya Yeremenko2 Roland Jacobs1 Reinhold E Schmidt1 Michael Bernateck3 Henning Zeidler4 Paul-Peter Tak2 Dominique Baeten2 and Markus Rihl1 1Clinic for Immunology and Rheumatology Hannover Medical School MHH Carl-Neuberg-Strasse 1 Hannover 30625 Germany 2Division of Clinical Immunology and Rheumatology Academic Medical Center AMC University of Amsterdam Meibergdreef 9 Amsterdam 1105 The Netherlands department of of Anesthesiology Pain Clinic Hannover Medical School MHH Carl-Neuberg-Strasse 1 Hannover 30625 Germany 4Rheumatologikum Hannover Rathenaustrasse 13 14 Hannover 30159 Germany Corresponding author Markus Rihl Received 12 Nov 2008 Revisions requested 16 Dec 2008 Revisions received 11 May 2009 Accepted 2 Jun 2009 Published 2 Jun 2009 Arthritis Research Therapy 2009 11 R82 doi ar2716 This article is online at http content 11 3 R82 2009 Barthel et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction We previously described the presence of nerve growth factor receptors in the inflamed synovial compartment. Here we investigated the presence of the corresponding nerve growth factors with special focus on nerve growth factor NGF . Methods mRNA expression levels of four ligands NGF brain derived growth factor BDNF neurotrophin NT -3 NT-4 and their four corresponding receptors tyrosine kinase trk A trkB trkC NGFRp75 were determined in the synovial fluid SF cells of 9 patients with rheumatoid arthritis RA and 16 with spondyloarthritis SpA and compared
