Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis: a prospective study of 124 cases. | Available online http content 11 3 R93 Research article Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis a prospective study of 124 cases Hui Zheng1 Yi Chen1 Wen Ao1 Yan Shen1 Xiao-wei Chen1 Min Dai1 Xiao-dong Wang1 Yu-cheng Yan2 and Cheng-de Yang1 1 Department of Rheumatology Renji Hospital Shanghai Jiaotong University School of Medicine 145 Shan Dong Zhong Road Shanghai 200001 PR China 2Department of Nephrology Renji Hospital Shanghai Jiaotong University School of Medicine 145 Shan Dong Zhong Road Shanghai 200001 PR China Contributed equally Corresponding author Cheng-de Yang yangchengde@ Received 17 Jan 2009 Revisions requested 6 Mar 2009 Revisions received 30 Apr 2009 Accepted 22 Jun 2009 Published 22 Jun 2009 Arthritis Research Therapy 2009 11 R93 doi ar2736 This article is online at http content 11 3 R93 2009 Zheng et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Glomerular microthrombosis GMT is a common vascular change in patients with lupus nephritis LN . The mechanism underlying GMT is largely unknown. Although several studies have reported the association of antiphospholipid antibodies aPL with GMT the relation between GMT and aPL remains controversial. Previous studies have demonstrated that some aPL could bind to several hemostatic and fibrinolytic proteases that share homologous enzymatic domains. Of the protease-reactive aPL some can inhibit the anticoagulant activity of activated protein C and the fibrinolytic function of plasmin and hinder the antithrombin inactivation of thrombin. The purpose of this study was to investigate the prevalence of GMT in LN patients and .
