Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Genome-wide association studies in systemic lupus erythematosus: a perspective. | Available online http content 11 4 119 Editorial Genome-wide association studies in systemic lupus erythematosus a perspective Deborah S Cunninghame Graham Molecular Genetics and Rheumatology Fifth Floor Commonwealth Building Room 5N8b Division of Medicine Imperial College Hammersmith Campus Du Cane Rd London W12 ONN Corresponding author Deborah S Cunninghame Graham Published 9 July 2009 Arthritis Research Therapy 2009 11 119 doi ar2739 This article is online at http content 11 4 119 2009 BioMed Central Ltd See related research by Suarez-Gestal et al. http content 11 3 R69 Abstract Genome-wide association studies GWAS have been shown to be a powerful way of identifying novel susceptibility genes in systemic lupus erythematosus SLE as demonstrated by a series of publications in the past year. Lupus has been a late-comer to the GWAS community being preceded by success stories for the GWAS approach in other autoimmune diseases including type I diabetes ankylosing spondylitis rheumatoid arthritis Crohn s disease and ulcerative colitis. The paper by Suarez-Gestal and colleagues seeks to exploit the wealth of data available from a total of four GWAS in SLE three in European-American populations and one in a Swedish population. The authors describe replication of ten lupus susceptibility alleles in a Spanish SLE case-control study. Suarez-Gestal and colleagues 1 selected single variants from either systemic lupus erythematosus SLE genomewide association studies GWAS or large candidate-genebased association studies. Three of the markers tested were identified in all three European-American GWAS. Four more were discovered in a single GWAS either the International Consortium for Systemic Lupus Erythematosus Genetics SLEGEN studies 2-4 or a Swedish study 5 . The remaining three variants were found in a smaller candidate-gene or regional association study. .