Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of interleukin-1β on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function. | Available online http content 11 4 R105 Research article Effect of interleukin-1 p on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function Luis Constandil1 Alejandro Hernandez1 Teresa Pelissier2 Osvaldo Arriagada1 Karla Espinoza1 Hector Burgos3 and Claudio Laurido1 Laboratory of Neurobiology Department of Biology Faculty of Chemistry and Biology University of Santiago of Chile Ave. Libertador B. O Higgins 3363 Casilla 40 Correo 33 Santiago Chile 2Program of Molecular and Clinical Pharmacology Institute of Biomedical Sciences ICBM Faculty of Medicine University of Chile Independencia 1027 . Box 70000 Santiago 7 Santiago Chile 3School of Psychology Las Americas University Ave. Libertad 1348 Vina del Mar Valparaiso Chile Corresponding author Luis Constandil Received 13 Mar 2009 Revisions requested 29 Apr 2009 Revisions received 9 Jun 2009 Accepted 8 Jul 2009 Published 8 Jul 2009 Arthritis Research Therapy 2009 11 R105 doi 86 ar2756 This article is online at http content 11 4 R105 2009 Constandil et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Cytokines produced by spinal cord glia after peripheral injuries have a relevant role in the maintenance of pain states. Thus while IL-1 p is overexpressed in the spinal cords of animals submitted to experimental arthritis and other chronic pain models intrathecal administration of IL-1p to healthy animals induces hyperalgesia and allodynia and enhances windup activity in dorsal horn neurons. Methods To investigate the functional contribution of glial cells in the spinal cord nociceptive transmission the effect of .
