Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link? | Available online http content 11 4 240 Review Gout Hyperuricemia and cardiovascular disease how strong is the evidence for a causal link Angelo L Gaffo1 N Lawrence Edwards2 and Kenneth G Saag3 1 Birmingham VA Medical Center. 700 19th St S. Birmingham AL 35233 USA 2Division of Rheumatology University of Florida. Gainesville FL 32610 USA 3Division of Clinical Immunology and Rheumatology University of Alabama at Birmingham FOT 820 1530 3rd Ave South Birmingham AL 35294 USA Corresponding author Kenneth G Saag ksaag@ Published 19 August 2009 This article is online at http content 11 4 240 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 240 doi ar2761 Abstract An association between high levels of serum urate and cardiovascular disease has been proposed for many decades. However it was only recently that compelling basic science data small clinical trials and epidemiological studies have provided support to the idea of a true causal effect. In this review we present recently published data that study the association between hyperuricemia and selected cardiovascular diseases with a final conclusion about the possibility of this association being causal. Introduction Hyperuricemia and gout are closely related conditions that are prevalent worldwide 1 2 . The impact of these conditions on quality of life and work productivity has been well described and for many years has been solely attributed to the burden caused by recurrent acute gout flares 3 4 . A possible link between hyperuricemia and cardiovascular disease has however been a debated clinical topic for many decades. Is hyperuricemia an independent cause of different types of cardiovascular disease In 1965 Sir Austin Bradford Hill presented considerations for epidemiological causation Table 1 5 . These considerations have limitations and exceptions but are nonetheless useful in trying to judge whether a given factor can make the leap from a .
