Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance? | Available online http content 11 5 246 Review Cytokines in chronic rheumatic diseases is everything lack of homeostatic balance Carlo Chizzolini1 Jean-Michel Dayer2 and Pierre Miossec3 1 Department of Immunology and Allergy University Hospital and School of Medicine Geneva University Hospital 1211 Geneva 14 Switzerland 2School of Medicine University of Geneva rue Michel Servet 1 1211 Geneva 14 Switzerland 3Department of Immunology and Rheumatology Hospital Edouard Herriot University of Lyon 69437 Lyon France Corresponding author Carlo Chizzolini Published 14 October 2009 This article is online at http content 11 5 246 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 246 doi ar2767 Abstract Biological systems have powerful inbuilt mechanisms of control intended to maintain homeostasis. Cytokines are no exception to this rule and imbalance in cytokine activities may lead to inflammation with subsequent tissue and organ damage altered function and death. Balance is achieved through multiple not mutually exclusive mechanisms including the simultaneous production of agonist and antagonistic cytokines expression of soluble receptors or membrane-bound nonsignaling receptors priming and or reprogramming of signaling and uncoupling of ligand receptor pairing from signal transduction. Insight into cytokine balance is leading to novel therapeutic approaches particularly in autoimmune conditions which are intimately linked to a dysregulated cytokine production. Introduction To explore the complex regulation of cytokine activities it may be of help to bear in mind the example of rheumatoid arthritis RA . A major step forward in RA treatment was achieved when it became possible to control disease manifestations such as joint destruction by blocking TNF. This could indicate that a single cytokine in this case TNF drives unopposed a series of events that lead to inflammation and destruction.
