Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of progressors in osteoarthritis by combining biochemical and MRI-based markers. | Available online http content 11 4 R115 Research article Identification of progressors in osteoarthritis by combining biochemical and MRI-based markers Erik B Dam1 Marco Loog1 2 3 Claus Christiansen1 Inger Byrjalsen1 Jenny Folkesson2 Mads Nielsen1 2 Arish A Qazi2 Paola C Pettersen4 Patrick Garnero5 and Morten A Karsdal1 Open Access 1Nordic Bioscience Herlev Hovedgade 207 2730 Herlev Denmark 2University of Copenhagen Department of Computer Science Universitetsparken 1 2100 Copenhagen Denmark 3Delft University of Technology Faculty of Electrical Engineering Mathematics and Computer Science Mekelweg 4 2628 CD Delft The Netherlands 4Center for Clinical and Basic Research Ballerup Byvej 222 2750 Ballerup Denmark 5CCBR-Synarc Molecular Markers Rue Montbrillant 16 69003 Lyon France Corresponding author Erik B Dam erikdam@ Received 6 Feb 2009 Revisions requested 14 Apr 2009 Revisions received 22 May 2009 Accepted 24 Jul 2009 Published 24 Jul 2009 Arthritis Research Therapy 2009 11 R115 doi 86 ar2774 This article is online at http content 11 4 R115 2009 Dam et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction At present no disease-modifying osteoarthritis drugs DMOADS are approved by the FDA Us Food and Drug Administration possibly partly due to inadequate trial design since efficacy demonstration requires disease progression in the placebo group. We investigated whether combinations of biochemical and magnetic resonance imaging MRI -based markers provided effective diagnostic and prognostic tools for identifying subjects with high risk of progression. Specifically we investigated aggregate cartilage longevity markers combining markers of
