Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis. | Available online http content 11 4 R116 Open Access Research article Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis Dimitrios Daoussis1 Vasileios Panoulas1 Tracey Toms1 Holly John1 loannis Antonopoulos1 Peter Nightingale2 Karen MJ Douglas1 Rainer Klocke1 and George D Kitas1 3 Department of Rheumatology Dudley Group of Hospitals NHS Trust Russells Hall Hospital Pensnett Road Dudley West Midlands DY1 2HQ UK 2Wolfson Laboratory Department of Medical Statistics School of Medicine University of Birmingham Queen Elizabeth Medical Centre Edgbaston Birmingham B15 2TH UK 3Arthritis Research Campaign Epidemiology Unit University of Manchester Oxford Road Stopford Building Manchester M13 9PT UK Corresponding author George D Kitas Received 6 May 2009 Revisions requested 23 Jun 2009 Revisions received 7 Jul 2009 Accepted 24 Jul 2009 Published 24 Jul 2009 Arthritis Research Therapy 2009 11 R116 doi 86 ar2775 This article is online at http content 11 4 R116 2009 Daoussis et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Recent evidence suggests that uric acid UA regardless of crystal deposition may play a direct pathogenic role in renal disease. We have shown that UA is an independent predictor of hypertension and cardiovascular disease CVD and that CVD risk factors associate with renal dysfunction in patients with rheumatoid arthritis RA . ln this study we investigated whether UA associates with renal dysfunction in patients with RA and whether such an association is independent or mediated through other comorbidities or risk factors for renal impairment. Methods Renal function was .
