Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis. | Available online http content 11 4 R128 Research article Reduced Fas ligand-expressing splenic CD5 B lymphocytes in severe collagen-induced arthritis Steven K Lundy1 2 and David A Fox1 2 Department of Internal Medicine Division of Rheumatology University of Michigan Medical School 4043 Biomedical Sciences Research Building Ann Arbor MI 48109-2200 USA 2Rheumatic Diseases Core Center University of Michigan Medical School 3918 Taubman Medical Center Ann Arbor MI 48109-5358 USA Corresponding author Steven K Lundy sklundy@ Received 30 Apr 2009 Revisions requested 7 Jul 2009 Revisions received 30 Jul 2009 Accepted 25 Aug 2009 Published 25 Aug 2009 Arthritis Research Therapy 2009 11 R128 doi 86 ar2795 This article is online at http content 11 4 R128 2009 Lundy and Fox licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The objective was to study immune regulation in a mouse model of rheumatoid arthritis that exhibits considerable heterogeneity of disease activity. Methods T-cell receptor transgenic mice in which nearly all CD4 T cells recognize a single peptide of type II collagen were immunized with collagen and observed for development of arthritis for 4 weeks. At 28 days post-immunization splenocytes were analyzed by flow cytometry and in vitro assays for markers of immune activation and regulation. Results Disease severities ranging from 0 to 12 on a 12-point scale were observed. Among splenic lymphocyte populations only the CD5 B-cell subset displayed a decrease in relative numbers as arthritis severity increased. Splenic CD5 B cells expressed higher levels of Fas ligand FasL than did CD4 T cells or CD5- B cells in all mice and .
