Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells. | Available online http content 11 5 R136 Research article Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells Sybille Franke1 Manfred Sommer1 Christiane Ruster1 Tzvetanka Bondeva1 Julia Marticke2 Gunther Hofmann2 Gert Hein1 and Gunter Wolf1 Open Access Department Internal Medicine III Jena University Hospital Erlanger Allee 101 Jena 07740 Germany department of Traumatology Hand and Reconstructive Surgery Jena University Hospital Erlanger Allee 101 Jena 07740 Germany Corresponding author Sybille Franke Received 3 Mar 2009 Revisions requested 6 Apr 2009 Revisions received 6 Aug 2009 Accepted 7 Sep 2009 Published 7 Sep 2009 Arthritis Research Therapy 2009 11 R136 doi 86 ar2807 This article is online at http content 11 5 R136 2009 Franke et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Advanced glycation end products AGEs have been introduced to be involved in the pathogenesis of osteoarthritis OA . The influence of AGEs on osteoarthritic fibroblast-like synovial cells FLS has been incompletely understood as yet. The present study investigates a potential influence of AGE-modified bovine serum albumin AGE-BSA on cell growth and on the expression of proinflammatory and osteoclastogenic markers in cultured FLS. Methods FLS were established from OA joints and stimulated with AGE-BSA- The mRNA expression of p27Kip1 RAGE receptor for AGEs nuclear factor kappa B subunit p65 NFkB p65 tumor necrosis factor alpha TNF-a interleukin-6 IL-6 receptor activator of NFkB ligand RANKL and osteoprotegerin was measured by real-time PCR. The respective .
