Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4. | Available online http content 11 5 R158 Research article Regulation of pathogenic IL-17 responses in collagen-induced arthritis roles of endogenous interferon-gamma and IL-4 Sujata Sarkar1 Laura A Cooney2 Peter White2 Deborah B Dunlop1 Judith Endres2 Julie M Jorns3 Matthew J Wasco3 and David A Fox2 Open Access Section of Rheumatology Department of Medicine University of Arizona 1501 N. Campbell Avenue Rm 6310 Tucson Arizona 85724 USA 2Division of Rheumatology Department of Internal Medicine and Rheumatic Disease Core Center University of Michigan 1500 E Medical Center Drive 3918 Taubman Center SPC 5358 Ann Arbor Michigan 48109 USA 3Department of Pathology University of Michigan 1301 Catherine 5240 Medical Science 1 Ann Arbor Michigan 48109 USA Contributed equally Corresponding author Sujata Sarkar ssarkar@ Received 9 Jan 2009 Revisions requested 19 Mar 2009 Revisions received 31 Aug 2009 Accepted 26 Oct 2009 Published 26 Oct 2009 Arthritis Research Therapy 2009 11 R158 doi 86 ar2838 This article is online at http content 11 5 R158 2009 Sarkar et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Interleukin IL -17 plays an important role in the pathogenesis of rheumatoid arthritis and the mouse model collagen-induced arthritis CIA . Interferon IFN -y and IL-4 have been shown to suppress Th17 development in vitro but their potential immunoregulatory roles in vivo are uncertain. The goals of this study were to determine the relationship between Th17 responses and disease severity in CIA and to assess regulation of IL-17 by endogenous IFN-y and IL-4. Methods DBA1 LacJ mice were immunized with type II collagen in complete Freund s .
