Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Utility of synovial biopsy. | Available online http content 11 6 256 Review Utility of synovial biopsy Stefan Vordenbaumen1 Leo AB Joosten2 Johannes Friemann3 Matthias Schneider1 and Benedikt Ostendorf1 1 Department of Endocrinology Diabetology and Rheumatology Heinrich Heine University 40225 Dusseldorf Germany 2Department of Medicine Radboud University Nijmegen Medical Centre . Box 9101 6500 HB Nijmegen The Netherlands institute for Pathology Markische Clinics 58151 Ludenscheid Germany Corresponding author Benedikt Ostendorf Ostendorf@ Published 23 November 2009 This article is online at http content 11 6 256 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 256 doi ar2847 Abstract Synovial biopsies gained either by blind needle biopsy or minimally invasive arthroscopy offer additional information in certain clinical situations where routine assessment has not permitted a certain diagnosis. In research settings synovial histology and modern applications of molecular biology increase our insight into pathogenesis and enable responses to treatment with new therapeutic agents to be assessed directly at the pathophysiological level. This review focuses on the diagnostic usefulness of synovial biopsies in the light of actual developments. Introduction The possibility of utilizing information from synovial biopsies as a diagnostic and research tool has attracted substantial interest amongst rheumatologists in the past few decades 1 2 . Its importance is likely to further increase in the near future for a number of reasons. First early diagnosis and immediate initiation of disease-modifying antirheumatic drug DMARD therapy in rheumatoid arthritis was shown to significantly improve outcome parameters 3 . Early rheumatoid arthritis RA however may not be unequivocally diagnosed in all cases based on clinical and serological criteria alone 4 . Histological analysis of synovial biopsies may prove to be valuable in .
