Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis. | Available online http content 11 6 R165 Research article Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes inhibition of IL-1p-induced NF-KB-mediated inflammation and apoptosis Constanze Csaki1 Ali Mobasheri2 and Mehdi Shakibaei1 Open Access Musculoskeletal Research Group Institute of Anatomy Ludwig-Maximilians-University Munich Pettenkoferstrasse 11 80336 Munich Germany 2Musculoskeletal Research Group Division of Veterinary Medicine School of Veterinary Medicine and Science Faculty of Medicine and Health Sciences University of Nottingham Sutton Bonington Campus Sutton Bonington LE1 2 5RD UK Corresponding author Mehdi Shakibaei Received 31 Aug 2009 Revisions requested 13 Oct 2009 Revisions received 21 Oct 2009 Accepted 4 Nov 2009 Published 4 Nov 2009 Arthritis Research Therapy 2009 11 R165 doi 86 ar2850 This article is online at http content 11 6 R165 2009 Csaki et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Currently available treatments for osteoarthritis OA are restricted to nonsteroidal anti-inflammatory drugs which exhibit numerous side effects and are only temporarily effective. Thus novel safe and more efficacious antiinflammatory agents are needed for OA. Naturally occurring polyphenolic compounds such as curcumin and resveratrol are potent agents for modulating inflammation. Both compounds mediate their effects by targeting the NF-kB signalling pathway. Methods We have recently demonstrated that in chondrocytes resveratrol modulates the NF-kB pathway by inhibiting the proteasome while curcumin modulates the activation of NF-kB by inhibiting upstream .
