Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Treatment of Lyme borreliosis. | Available online http content 11 6 258 Review Treatment of Lyme borreliosis Hermann J Girschick1 2 Henner Morbach1 and Dennis Tappe3 1 Paediatric Rheumatology Immunology Osteology and Infectious Diseases Children s Hospital University of Wuerzburg Josef-Schneider-Str. 2 97080 Wuerzburg Germany 2Paediatric Rheumatology Immunology Osteology and Infectious Diseases Vivantes Friedrichshain Children s Hospital Landsberger Allee 49 10249 Berlin Germany institute of Hygiene and Microbiology University of Wuerzburg 97080 Wuerzburg Germany Corresponding author Hermann Girschick Published 17 December 2009 This article is online at http content 11 6 258 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 258 doi ar2853 Abstract Borrelia burgdorferi sensu lato is the causative agent of Lyme borreliosis in humans. This inflammatory disease can affect the skin the peripheral and central nervous system the musculoskeletal and cardiovascular system and rarely the eyes. Early stages are directly associated with viable bacteria at the site of inflammation. The pathogen-host interaction is complex and has been elucidated only in part. B. burgdorferi is highly susceptible to antibiotic treatment and the majority of patients profit from this treatment. Some patients develop chronic persistent disease despite repeated antibiotics. Whether this is a sequel of pathogen persistence or a status of chronic auto-inflammation auto-immunity or a form of fibromyalgia is highly debated. Since vaccination is not available prevention of a tick bite or chemoprophylaxis is important. If the infection is manifest then treatment strategies should target not only the pathogen by using antibiotics but also the chronic inflammation by using anti-inflammatory drugs. Introduction In recent decades much has been learned about the aetiology of Borrelia burgdorferi infection and the transmitting .