Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Microparticles as biomarkers in autoimmunity: from dust bin to center stage. | Available online http content 11 6 135 Editorial Microparticles as biomarkers in autoimmunity from dust bin to center stage David S Pisetsky Medical Research Service Durham VA Medical Center Division of Immunology and Rheumatology Duke University Medical Center 151G Durham VAMC 508 Fulton Street Durham NC 27705 USA Corresponding author David S Pisetsky piset001@ Published 30 November 2009 Arthritis Research Therapy 2009 11 135 doi ar2856 This article is online at http content 11 6 135 2009 BioMed Central Ltd See reltade research by Sellam et al. http content 11 5 R156 Abstract Microparticles are small membrane-bound vesicles released from activated and dying cells. As shown in a study of primary Sjogren s syndrome systemic lupus erythematosus and rheumatoid arthritis levels of microparticles in the blood as measured by a solid-phase prothrombinase assay or flow cytometry are increased with autoimmunity. Among patients with these conditions however particle numbers were inversely related to disease activity and levels of the enzyme secretory phospholipase A2 that can digest membrane lipids and perhaps cause particle loss. These findings suggest microparticles as novel biomarkers for autoimmunity with levels reflecting events leading to their loss as well as production. The development of biomarkers for autoimmunity is a major undertaking critical to elucidating disease pathogenesis and assessing disease activity in routine care as well as in clinical trials. In general biomarkers represent products of cells for example cytokines or phenotypic or functional changes in cells usually sampled from the blood. These changes include the expression of cell surface markers or patterns of gene expression. As shown in the previous issue of Arthritis Research and Therapy subcellular fragments called microparticles MPs may represent novel biomarkers that can occupy an important place between
