Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis. | Uller et al. Respiratory Research 2010 11 54 http content 11 1 54 RESPIRATORY RESEARCH RESEARCH Open Access Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis Lena Uller 1 Cecilia Ahlstrom Emanuelsson 2 Morgan Andersson2 Jonas S Erjefalt 1 Lennart Greiff2 and Carl G Persson3 Abstract Background It is widely assumed that apoptosis of eosinophils is a central component of resolution of allergic airway disease. However this has not been demonstrated in human allergic airways in vivo. Based on animal in vivo observations we hypothesised that steroid-induced resolution of human airway eosinophilic inflammation involves inhibition of CCL5 RANTES a CC-chemokine regulating eosinophil and lymphocyte traffic and elimination of eosinophils without evident occurrence of apoptotic eosinophils in the diseased tissue. Objective To determine mucosal eosinophilia apoptotic eosinophils general cell apoptosis and cell proliferation and expression of CCL5 and CCL11 eotaxin in human allergic airway tissues in vivo at resolution of established symptomatic eosinophilic inflammation. Methods Twenty-one patients with intermittent birch and or grass allergic rhinitis received daily nasal allergen challenges for two seven days periods separated by more than two weeks washout. Five days into these artificial pollen seasons nasal treatment with budesonide was instituted and continued for six days in a double blinded randomized placebo-controlled and crossover design. This report is a parallel group comparison of nasal biopsy histochemistry data obtained on the final day of the second treatment period. Results Treatments were instituted when clinical rhinitis symptoms had been established. Compared to placebo budesonide reduced tissue eosinophilia and subepithelial more than epithelial eosinophilia. Steroid treatment also attenuated tissue expression of CCL5 but CCL11 was not reduced. General tissue cell apoptosis and epithelial cell .
