Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Colour of sputum is a marker for bacterial colonisation in chronic obstructive pulmonary disease. | Miravitlles et al. Respiratory Research 2010 11 58 http content 11 1 58 RESPIRATORY RESEARCH RESEARCH Open Access Colour of sputum is a marker for bacterial colonisation in chronic obstructive pulmonary disease Marc Miravitlles 1 Alicia Marin2 Eduard Monsó3 Sara Vilà1 Cristian de la Roza4 Ramona Hervás3 Cristina Esquinas1 Marian García3 Laura Millares3 Josep Morera3 and Antoni Torres5 Abstract Background Bacterial colonisation in chronic obstructive pulmonary disease COPD contributes to airway inflammation and modulates exacerbations. We assessed risk factors for bacterial colonisation in COPD. Methods Patients with stable COPD consecutively recruited over 1 year gave consent to provide a sputum sample for microbiologic analysis. Bronchial colonisation by potentially pathogenic microorganisms PPMs was defined as the isolation of PPMs at concentrations of 102 colony-forming units CFU mL on quantitative bacterial culture. Colonised patients were divided into high 105 CFU mL or low 105 CFU mL bacterial load. Results A total of 119 patients men mean age 68 years mean forced expiratory volume in one second FEV1 predicted were evaluated. Bacterial colonisation was demonstrated in 58 patients. Patients with and without bacterial colonisation showed significant differences in smoking history cough dyspnoea COPD exacerbations and hospitalisations in the previous year and sputum colour. Thirty-six patients 62 of those colonised had a high bacterial load. More than 80 of the sputum samples with a dark yellow or greenish colour yielded PPMs in culture. In contrast only of white and of light yellow sputum samples were positive P . Multivariate analysis showed an increased degree of dyspnoea odds ratio OR 95 confidence interval CI P and a darker sputum colour OR 95 CI P as factors associated with the presence of PPMs in sputum. Conclusions Almost half of our population of ambulatory
